a^x
Radiation induced Allele Detail

Summary

• Symbol: a^x
• Name: nonagouti; lethal nonagouti
• MGI ID: MGI:1855944
• Synonyms: a(x)
• Gene: a Location: Chr2:154792519-154892932 bp, + strand Genetic Position: Chr2, 76.83 cM
• Alliance: a^x page

Mutation origin

• Strain of Origin: (C3H/Rl x 101/Rl)F1

Mutation description

• Allele Type: Radiation induced
• Mutation: Intergenic deletion
• Mutation details: This allele comprises a deletion of approximately 100 kb, which does not affect agouti coding sequences, but begins 4 kb 3' of the last exon, and thus may affect coat color by removing an agouti 3' enhancer. The Ahcy gene, which codes for the enzyme S-adenosylhomocysteine hydrolase (SAHase), is contained within a 20 kb region within the a(x) deletion. (J:17867)
• Inheritance: Other (see notes)

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any a Mutation: 463 strains or lines available

Notes

a^x is recessive to A^y, A^w, A, and a^t, and dominant to a.

References

• Original: J:174047 Russell LB, et al., Crossing over within the a "locus" of the mouse. Genetics. 1963;48:907 Abstr
• All: 7 reference(s)