A^hvy
Spontaneous Allele Detail

Summary

• Symbol: A^hvy
• Name: nonagouti; hypervariable yellow
• MGI ID: MGI:1855945
• Gene: a Location: Chr2:154792519-154892932 bp, + strand Genetic Position: Chr2, 76.83 cM
• Alliance: A^hvy page

Mutation origin

• Strain of Origin: C3H/HeJ

Mutation description

• Allele Type: Spontaneous
• Mutation: Transposon insertion
• Mutation details: Sequencing of 5' RACE and genomic PCR products revealed that this allele resulted from the integration of an intracisternal A particle (IAP) in an antisense orientation within the 5'untranslated region of exon 1C. Methylation assay results indciate that the agouti and yellow mosaic phenotype characteristic of this allele is due to differential epigenetic methylation of the IAP. (J:31145, J:79708)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any a Mutation: 463 strains or lines available

References

• Original: J:24247 Siracusa LD, et al., Hypervariable yellow (Ahvy), a new murine agouti mutation: Ahvy displays the largest variation in coat color phenotypes of all known agouti alleles. J Hered. 1995 Mar-Apr;86(2):121-8
• All: 4 reference(s)