Tyrp1^b
Spontaneous Allele Detail

Summary

• Symbol: Tyrp1^b
• Name: tyrosinase-related protein 1; brown
• MGI ID: MGI:1855960
• Synonyms: b
• Gene: Tyrp1 Location: Chr4:80752360-80769956 bp, + strand Genetic Position: Chr4, 37.89 cM
• Alliance: Tyrp1^b page

a/a Tyrp1^b/Tyrp1^b

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: old mutant of the mouse fancy

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: A G-to-A transition point mutation at position 329 was shown by revertant analysis to be responsible for the mutant phenotype seen in the brown mutant. This mutation changes cysteine to tyrosine at position 110 (p.C110Y) in the encoded protein. Three other point mutations in the brown sequence were identified, but do not contribute to the mutant phenotype. (J:44435)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	2 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tyrp1^b

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 29 strains available Cell Lines: 0 lines available
• Carrying any Tyrp1 Mutation: 162 strains or lines available

References

• Original: J:30758 Gruneberg H, The Genetics of the Mouse, second edition, in The Genetics of the Mouse. 1952
• All: 38 reference(s)