Tyrp1^b-c
Spontaneous Allele Detail

Summary

• Symbol: Tyrp1^b-c
• Name: tyrosinase-related protein 1; brown cordovan
• MGI ID: MGI:1855961
• Synonyms: Tyrp1^b-cJ
• Gene: Tyrp1 Location: Chr4:80752360-80769956 bp, + strand Genetic Position: Chr4, 37.89 cM
• Alliance: Tyrp1^b-c page

Mutation origin

• Strain of Origin: (DBA/1 x C57BL/10)F1

Mutation description

• Allele Type: Spontaneous
• Mutation: Undefined
• Mutation details: Complementation testing demonstrated that this mutation is an allele of the original brown (Tyrp1^b) mutation. The Tyrp1^b-c allele was found among (DBA/1 X C57BL/10)F1 offspring. Because DBA is homozygous for Tyrp1^b, the mutation occurred on C57BL10.
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Tyrp1 Mutation: 162 strains or lines available

Notes

Homozygous recessive mutant on a nonagouti/black background are chocolate brown and show altered melanin granule morphology. Semidominant mutants result in melanocyte degeneration causing reduced pigmentation and progressive hearing loss.

References

• Original: J:15167 Miller DS, et al., Cordovan, a new allele of black and brown color in the mouse. J Hered. 1955;46(6):293-96
• All: 3 reference(s)