Tyr^c-e
Spontaneous Allele Detail

Summary

• Symbol: Tyr^c-e
• Name: tyrosinase; extreme dilution
• MGI ID: MGI:1855978
• Synonyms: c^d, c^e
• Gene: Tyr Location: Chr7:87073979-87142637 bp, - strand Genetic Position: Chr7, 49.01 cM
• Alliance: Tyr^c-e page

Mutation origin

• Strain of Origin: wild

Mutation description

• Allele Type: Spontaneous
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Tyr Mutation: 379 strains or lines available

Notes

Tyr^c-e, extreme dilution. This mutation was found in the wild by Detlefsen (J:34484). Hair is very light gray, and eyes are black. Melanin granules of both retinal and neural-crest derived melanocytes are pigmented but are smaller and fewer than normal (J:12970, J:5001). Tyrosinase activity in the skin is very low (J:30744). Tyr^c-e/Tyr^c mice are almost white with black eyes.

References

• Original: J:34484 Detlefsen JA, A new mutation in the house mouse. Am Naturalist. 1921 Sep-Oct;55:469-73
• All: 12 reference(s)