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Acancmd-Bc
Spontaneous Allele Detail
Summary
Symbol: Acancmd-Bc
Name: aggrecan; cartilage matrix deficiency British Columbia
MGI ID: MGI:1855999
Synonyms: cmd-Bc
Gene: Acan  Location: Chr7:78703231-78764847 bp, + strand  Genetic Position: Chr7, 44.88 cM
Alliance: Acancmd-Bc page
Mutation
origin
Strain of Origin:  BALB/cGaBc
Mutation
description
Allele Type:    Spontaneous
Mutation:    Intragenic deletion
 
Mutation detailsThis allele comprises a deletion resulting in the complete loss of exons 2 to 18, resulting in a significantly shortened mRNA. The upstream breakpoint is in intron 1, 18.8 kb 3' of exon 1; the downstream breakpoint lies 10.5 kb past the final aggrecan exon 18. (J:58755)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 15 assay results
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acan Mutation:  80 strains or lines available
References
Original:  J:65316 Juriloff DM, et al., Agccmd-Bc - cartilage matrix deficiency-British Columbia. Mouse News Lett. 1985;72:95
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory