Lepr^db-3J
Spontaneous Allele Detail

Summary

• Symbol: Lepr^db-3J
• Name: leptin receptor; diabetes 3 Jackson
• MGI ID: MGI:1856012
• Gene: Lepr Location: Chr4:101574601-101672549 bp, + strand Genetic Position: Chr4, 46.96 cM
• Alliance: Lepr^db-3J page

Lepr^db-3J/Lepr^db-3J

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: 129P3/J

Mutation description

• Allele Type: Spontaneous
• Mutation: Intragenic deletion
• Mutation details: Sequence analysis of the 3J allele revealed a 17 nucleotide deletion beginning at base 1874. This deletion results in a shift of the reading frame, and a premature termination of the protein at the 11th amino acid after the deletion site. The mutation is predicted to result in a truncated receptor without a transmembrane domain and affects all Lepr splice variants. (J:40658)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lepr Mutation: 122 strains or lines available

References

• Original: J:6337 Leiter EH, et al., A new mutation (db3J) at the diabetes locus in strain 129/J mice. I. Physiological and histological characterization. Diabetologia. 1980 Jul;19(1):58-65
• All: 10 reference(s)