Lepr^db-Pas
Spontaneous Allele Detail

Summary

• Symbol: Lepr^db-Pas
• Name: leptin receptor; diabetes Institut Pasteur
• MGI ID: MGI:1856013
• Synonyms: db^Pas, diabetes-Pasteur, obese-like
• Gene: Lepr Location: Chr4:101574601-101672549 bp, + strand Genetic Position: Chr4, 46.96 cM
• Alliance: Lepr^db-Pas page

Mutation origin

• Strain of Origin: DW/Pas

Mutation description

• Allele Type: Spontaneous
• Mutation: Duplication
• Lepr^db-Pas involves 1 genes/genome features (Lepr) View all
• Mutation details: Southern analysis indicates that the mutation in the Pas allele is a partial duplication of the coding sequence for the putative extracellular domain of the protein. (J:31419, J:49607)
• Inheritance: Recessive

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lepr Mutation: 122 strains or lines available

References

• Original: J:31095 Guenet JL, A mutation in the DW inbred line producting an obese phenotype. Mouse News Lett. 1982;67:30
• All: 7 reference(s)