Pou1f1^dw-J
Spontaneous Allele Detail

Summary

• Symbol: Pou1f1^dw-J
• Name: POU domain, class 1, transcription factor 1; dwarf Jackson
• MGI ID: MGI:1856025
• Synonyms: dwarf-J, dwJ, Pit1^dwJ
• Gene: Pou1f1 Location: Chr16:65317397-65331183 bp, + strand Genetic Position: Chr16, 37.25 cM
• Alliance: Pou1f1^dw-J page

Mutation origin

• Strain of Origin: C3H/HeJ

Mutation description

• Allele Type: Spontaneous
• Mutation: Other
• Mutation details: The mutation was characterized by Southern blot as either a chromosomal inversion or an insertion of greater than 4kb in the gene. PCR analysis revealed that most of exon 3 is intact, but the exact break points are not established. (J:10774, J:10998)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pou1f1 Mutation: 21 strains or lines available

Notes

This remutation of the Snell dwarf gene occurred in the C3H/HeJ strain (J:6342). Mutant mice homozygous for Pit1^dw-J, like homozygotes for Pit1^dw, lack PIT1 protein activity and have no lactotrophs, thyrotrophs, or somatotrophs (J:10774).

References

• Original: J:6342 Eicher EM, et al., New mouse dw allele: genetic location and effects on lifespan and growth hormone levels. J Hered. 1980 May-Jun;71(3):187-90
• All: 19 reference(s)