Lama2^dy
Spontaneous Allele Detail

Summary

• Symbol: Lama2^dy
• Name: laminin, alpha 2; dystrophia muscularis
• MGI ID: MGI:1856026
• Synonyms: dy
• Gene: Lama2 Location: Chr10:26857281-27493021 bp, - strand Genetic Position: Chr10, 14.23 cM, cytoband A4-B1
• Alliance: Lama2^dy page

Lama2^dy/Lama2^dy and control

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: 129P1/Re

Mutation description

• Allele Type: Spontaneous
• Mutation: Undefined
• Mutation details: Analysis of Lama2 expression of dystrophic dy mice revealed a specific deficiency of this mRNA in skeletal muscle, cardiac muscle, and peripheral nerve. (J:18187, J:44989)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	9 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	15 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Lama2^dy

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Lama2 Mutation: 177 strains or lines available

Notes

This mutation arose spontaneously in the 129/Re inbred strain at The Jackson Laboratory in 1951.

References

• Original: J:13125 Michelson AM, et al., Dystrophia muscularis: a hereditary primary myopathy in the house mouse. Proc Natl Acad Sci U S A. 1955 Dec 15;41(12):1079-1084
• All: 77 reference(s)