Lama2^dy-2J
Spontaneous Allele Detail

Summary

• Symbol: Lama2^dy-2J
• Name: laminin, alpha 2; dystrophia muscularis 2 Jackson
• MGI ID: MGI:1856027
• Synonyms: 2J, dy^2J
• Gene: Lama2 Location: Chr10:26857281-27493021 bp, - strand Genetic Position: Chr10, 14.23 cM, cytoband A4-B1
• Alliance: Lama2^dy-2J page

Lama2^dy-2J/Lama2^dy-2J mouse

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: WK/ReJ

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: The G-to-A mutation eliminates a splice donor site by changing it from C-GT to C-AT, which causes abnormal splicing and expression of multiple aberrant mRNAs variants. One mRNA is translated into an alpha 2 polypeptide with a deletion in domain VI. (J:21367, J:25954)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	25 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lama2 Mutation: 177 strains or lines available

References

• Original: J:5151 Meier H, et al., Muscular dystrophy in the mouse caused by an allele at the dy-locus. Life Sci. 1970 Feb 8;9(3):137-44
• All: 47 reference(s)