Ift56^hop
Spontaneous Allele Detail

Summary

• Symbol: Ift56^hop
• Name: intraflagellar transport 56; hop sterile
• MGI ID: MGI:1856054
• Gene: Ift56 Location: Chr6:38358404-38404582 bp, + strand Genetic Position: Chr6, 17.76 cM
• Alliance: Ift56^hop page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Single point mutation
• Mutation details: The molecular lesion is a C-to-A point mutation (c.1290C>A) that changes a tyrosine codon to a stop codon (p.Y430*) in exon 15. This mutation arose spontaneously in an unirradiated stock at the MRC Radiobiology Unit at Harwell in 1967. RT-PCR indicates expression of the mRNA was reduced 5.7-fold compared to that of the wild-type mRNA in MEFs. (J:216284)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	40 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ift56 Mutation: 32 strains or lines available

References

• Original: J:5206 Johnson DR, et al., Hop-sterile, a mutant gene affecting sperm tail development in the mouse. J Embryol Exp Morphol. 1971 Apr;25(2):223-36
• All: 6 reference(s)