Lbr^ic-J
Spontaneous Allele Detail

Summary

• Symbol: Lbr^ic-J
• Name: lamin B receptor; ichthyosis Jackson
• MGI ID: MGI:1856064
• Synonyms: ic^J
• Gene: Lbr Location: Chr1:181642880-181669933 bp, - strand Genetic Position: Chr1, 84.89 cM
• Alliance: Lbr^ic-J page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Spontaneous
• Mutation: Insertion
• Mutation details: This phenotypic mutant was found to be allelic to ic by complementation testing. The mutation in the Lbr^ic-J mouse was identified as 2 bp insertion at position 1088. This insertion results in a frame shift, changing amino acids 365-385, and creates a premature stop codon at amino acid position 386. (J:80915)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lbr Mutation: 57 strains or lines available

References

• Original: J:24755 Eicher EM, Spontaneous mutations - streaker (nu^str) and ichthyosis (ic^J). Mouse News Lett. 1976;54:40
• All: 9 reference(s)