Scn8a^med-jo
Spontaneous Allele Detail

Summary

• Symbol: Scn8a^med-jo
• Name: sodium channel, voltage-gated, type VIII, alpha; jolting
• MGI ID: MGI:1856080
• Synonyms: jo, med^jo
• Gene: Scn8a Location: Chr15:100767739-100943819 bp, + strand Genetic Position: Chr15, 56.39 cM, cytoband F1
• Alliance: Scn8a^med-jo page

Mutation origin

• Strain of Origin: DBA/2WyDi

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: A transition point mutation that altered coding nucleotide 3949 from G-to-A, which replaces the alanine at residue 1317 with threonine (p.A1317T). The mutation is located in a region of the ion channel that is predicted to encode the cytoplasmic linker between integral membrane segments S4 and S5 in domain III. (J:35567)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Scn8a Mutation: 99 strains or lines available

References

• Original: J:15056 Dickie MM, Jolting. Mouse News Lett. 1965;32:44
• All: 13 reference(s)