Mitf^Mi-b
Spontaneous Allele Detail

Summary

• Symbol: Mitf^Mi-b
• Name: melanogenesis associated transcription factor; microphthalmia brownish
• MGI ID: MGI:1856086
• Gene: Mitf Location: Chr6:97784013-97998310 bp, + strand Genetic Position: Chr6, 45.05 cM
• Alliance: Mitf^Mi-b page

Mutation origin

• Strain of Origin: T stock x (101/Rl x C3H/Rl)F1

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: G-to-A transition leading to a p.Gly244Glu substitution in the encoded protein. This amino acid is in helix 2 of the HLH dimerization domain. (J:37067)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mitf Mutation: 74 strains or lines available

References

• Original: J:15061 Larsen M, Microphthalmia-brownish, Mi^b. Mouse News Lett. 1966;34:41
• All: 5 reference(s)