Mitf^Mi-Or
Radiation induced Allele Detail

Summary

• Symbol: Mitf^Mi-Or
• Name: melanogenesis associated transcription factor; microphthalmia Oak Ridge
• MGI ID: MGI:1856087
• Synonyms: Mi^or
• Gene: Mitf Location: Chr6:97784013-97998310 bp, + strand Genetic Position: Chr6, 45.05 cM
• Alliance: Mitf^Mi-Or page

Mutation origin

• Strain of Origin: (101/Rl x C3H/Rl)F1

Mutation description

• Allele Type: Radiation induced
• Mutation: Single point mutation
• Mutation details: G to A transition at nucleotide 776 which leads to an arginine to lysine substitution at the corresponding amino acid (216) in the basic region of the encoded protein. (J:21366)
• Inheritance: Semidominant

Disease models

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mitf Mutation: 74 strains or lines available

Notes

Mitf^Mi-Or/Mitf^Mi mice resemble homozygous Mitf^Mi-Or; Mitf^Mi-Or/Mitf^Mi-b mice resemble Mitf^Mi-b homozygotes (J:15060).

References

• Original: J:13426 Stelzner KF, Dominant mutation resembling Mi. Mouse News Lett. 1964;31:40-41
• All: 12 reference(s)