Mitf^Mi-wh
Spontaneous Allele Detail

Summary

• Symbol: Mitf^Mi-wh
• Name: melanogenesis associated transcription factor; white
• MGI ID: MGI:1856088
• Synonyms: mitf^wh, Mi^wh
• Gene: Mitf Location: Chr6:97784013-97998310 bp, + strand Genetic Position: Chr6, 45.05 cM
• Alliance: Mitf^Mi-wh page

Mitf^Mi-wh/+ and Mitf^Mi-wh/Mitf^Mi-wh and control

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: (C57BL x DBA)F1

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: T-to-A transversion at bp 764, which leads to an isoleucine to asparagine substitution at amino acid 212 in the encoded protein (p.I212N). This mutation is in the basic region of the protein. (J:19656, J:21366)
• Inheritance: Semidominant

Disease models

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	20 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 8 strains available Cell Lines: 0 lines available
• Carrying any Mitf Mutation: 74 strains or lines available

Notes

Combination heterozygotes of Mitf^Mi-wh/Mitf^Mi, Mitf^Mi-wh/Mitf^Mi-b, and Mitf^Mi-wh/Mitf^Mi-ws show some interallelic complementation in that the heterozygote of the two alleles is more nearly normal than either homozygote (J:12967, J:19656). Mitf^Mi-b/Mitf^Mi-wh agouti mice are light cream with white spots and ruby eyes (J:15061).

References

• Original: J:13058 Grobman AB, et al., Mutant white mice. A new dominant autosomal mutant affecting coat color in Mus musculus. J Hered. 1947;38:381-384
• All: 41 reference(s)