Atp7a^Mo-to
Spontaneous Allele Detail

Summary

• Symbol: Atp7a^Mo-to
• Name: ATPase, copper transporting, alpha polypeptide; tortoiseshell
• MGI ID: MGI:1856101
• Gene: Atp7a Location: ChrX:105070882-105168532 bp, + strand Genetic Position: ChrX, 47.36 cM
• Alliance: Atp7a^Mo-to page

Atp7a^Mo-to/Atp7a⁺

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: obese stock

Mutation description

• Allele Type: Spontaneous
• Mutation: Undefined
• A spontaneous mutation that arose at The Jackson Laboratory in 1952.
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Atp7a Mutation: 69 strains or lines available

Notes

Atp7a^Mo-to, tortoiseshell, semidominant. Arising spontaneously in an obese stock, the tortoiseshell mutation was considered to be a mottled locus allele because of its interaction with other alleles at the locus and because it shows about the same linkage relation with Zic3 (bent tail) as Atp7a^Mo (J:13382). Heterozygous females resemble Atp7a^/+ females in color. The vibrissae are slightly wavy and the coat has a slightly silky texture. The distribution of patches of wild-type and white color is different from the distribution of patches of wild-type and wavy hair, suggesting that Atp7a^Mo-to probably acts independently in melanoblasts and hair follicles (J:15324). Most hemizygous males die before birth (J:24988), but a few are stillborn (J:12963). Using as parent a male presumed to be chimeric for Atp7a^Mo-to/Y and +/Y, Grahn et al. (J:12963) showed that homozygous Atp7a^Mo-to/Atp7a^Mo-to and heterozygous Atp7a^Mo-to/Atp7a^Mo-dp females die in utero, while heterozygous Atp7a^Mo-to/Atp7a^Mo-blo and Atp7a^Mo-to/Atp7a^Mo-br females reach term, but die by 15 days of age. The elastic lamina of the aorta is defective in stillborn hemizygous Atp7a^Mo-to males and in 40 per cent of Atp7a^Mo-to/+ female heterozygotes.

References

• Original: J:24988 Dickie MM, The Tortoise Shell House Mouse. J Hered. 1954;45(4):158-90
• All: 11 reference(s)