Oca2^p-cp
Radiation induced Allele Detail

Summary

• Symbol: Oca2^p-cp
• Name: oculocutaneous albinism II; pink-eyed dilution cleft palate
• MGI ID: MGI:1856116
• Synonyms: p^11H, p^cp
• Gene: Oca2 Location: Chr7:55889508-56186266 bp, + strand Genetic Position: Chr7, 33.44 cM
• Alliance: Oca2^p-cp page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Radiation induced
• Mutation: Deletion
• Oca2^p-cp involves 4 genes/genome features (Gabrg3, Gabra5, Mir6389 ...) View all
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Oca2 Mutation: 70 strains or lines available

Notes

This mutation was found in the progeny of a neutron-irradiated male. Most homozygotes die soon after birth with cleft palate, but a few, presumably with unaffected or slightly affected palates, survive to maturity and are fertile. Female fertility is reduced; males have not been tested (J:2108). The p^cp mutation has been shown to be a deletion, which disrupts genes for three gamma-aminobutyric acid type A receptors, Gabra5, Gabrb3, and Gabrg3, which are clustered on Chr 7. The human homologs of these receptor genes are closely linked with the genes for Angelman and Prader-Willi syndromes (J:13583).

References

• Original: J:13618 Phillips RJS, p¹¹, a pink-eyed allele. Mouse News Lett. 1973;48:30
• All: 9 reference(s)