Oca2^p-25H
Radiation induced Allele Detail

Summary

• Symbol: Oca2^p-25H
• Name: oculocutaneous albinism II; pink-eyed dilution 25 Harwell
• MGI ID: MGI:1856126
• Synonyms: Herc2^p-25H, p^25H
• Gene: Oca2 Location: Chr7:55889508-56186266 bp, + strand Genetic Position: Chr7, 33.44 cM
• Alliance: Oca2^p-25H page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Radiation induced
• Mutation: Inversion
• Oca2^p-25H involves 1 genes/genome features (Oca2) View all
• Mutation details: Southern blot analyses using cDNA probes from the pink-eyed dilution locus show that this allele comprises an inversion of a segment of Chromsome 7 that alters the 5'end of the Oca2^p gene preventing transcription of p. (J:2206)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Oca2 Mutation: 70 strains or lines available

Notes

p^25H, p-25 Harwell, recessive. This allele was neutron-irradiation-induced. Homozygotes are very similar to p^6H homozygotes, except that sperm morphology differs; p^25H homozygous males have a lower proportion of normal sperm (J:5219, J:5501, J:15082, J:5808). The sperm shows a loss of negative charge along the whole length of the tail (defined by the inability to stain with the positively charged colloidal iron hydroxide), suggesting that the defect in spermatogenesis may involve the Golgi apparatus and/or plasma membrane (J:11957). Females have reduced fertility. In addition, in p^25H homozygotes of both sexes, the pars nervosa of the pituitary contains degenerating nerve axons (J:5508), and the hypothalamus has reduced binding capacity for estradiol-17 (J:5219). Mutant females can generally produce a small, first litter, but the pups often die neonatally due to poor maternal behavior, which may involve improper nesting (J:49046).

References

• Original: J:64106 Johnson DR, et al., p^25H - pink eyed 25 Harwell. Mouse News Lett. 1972;47:52
• All: 14 reference(s)