Kitl^Sl-con
Radiation induced Allele Detail

Summary

• Symbol: Kitl^Sl-con
• Name: kit ligand; steel contrasted
• MGI ID: MGI:1856163
• Synonyms: Mgf
• Gene: Kitl Location: Chr10:99851492-99936278 bp, + strand Genetic Position: Chr10, 51.4 cM
• Alliance: Kitl^Sl-con page

Mutation origin

• Strain of Origin: (C3H/HeH x 101/H)F1

Mutation description

• Allele Type: Radiation induced
• Mutation: Other
• Mutation details: Pulse field gel electrophoresis using cDNA and genomic clones showed that this allele is an undefined rearrangement between 90 and 2.2Mb 5' to Kitl. Northern analysis showed that the mRNA transcript is of normal size but this allele exerts tissue-specific effects on transcript abundance. (J:23593)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kitl Mutation: 94 strains or lines available

Notes

The contrasted mutation was found in a neutron irradiation experiment. Heterozygotes are recognizable soon after birth by dark pigmentation of the genital papilla. The adult coat is slightly lighter than normal. Homozygotes also have dark external genitalia but a markedly diluted coat; they have a mild macrocytic anemia. Males are fertile but females are usually sterile (J:20215).

References

• Original: J:20215 Searle AG, New mutant (Contrasted). Mouse News Lett. 1968;38:22
• All: 8 reference(s)