Kitl^Sl-d
Spontaneous Allele Detail

Summary

• Symbol: Kitl^Sl-d
• Name: kit ligand; steel Dickie
• MGI ID: MGI:1856164
• Synonyms: KL, MGF, Mgf^Sl-d, Sl^d, Sld, W/Wv
• Gene: Kitl Location: Chr10:99851492-99936278 bp, + strand Genetic Position: Chr10, 51.4 cM
• Alliance: Kitl^Sl-d page

Kitl^Sl/Kitl^Sl-d mouse

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: DBA/2J

Mutation description

• Allele Type: Spontaneous (Modified isoform(s))
• Mutation: Intragenic deletion
• Mutation details: A 4kb deletion in genomic DNA results in the absence of 241bp in the mRNA and the addition of 67bp of novel sequence, a 174bp net loss. The region that is deleted corresponds to 5 amino acids N-terminal to the transmembrane domain of the encoded protein, and results in termination of the open reading frame after an additional 3 amino acids. The resulting protein is a soluble truncated one, lacking both transmembrane and cytoplasmic domains. Northern analysis indicates that mRNA is transcribed at nearly wild-type levels in adult tissues. (J:10750, J:20286, J:40339)
• Inheritance: Semidominant

Expression

In Mice Carrying this Mutation:	26 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Kitl^Sl-d

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Kitl Mutation: 94 strains or lines available

Notes

Genbank ID for this allele: M64262

References

• Original: J:13392 Bernstein S, Steel Dickie. Mouse News Lett. 1960;23:33-4
• All: 78 reference(s)