Otc^spf
Radiation induced Allele Detail

Summary

• Symbol: Otc^spf
• Name: ornithine transcarbamylase; sparse fur
• MGI ID: MGI:1856178
• Synonyms: spf
• Gene: Otc Location: ChrX:10118584-10187275 bp, + strand Genetic Position: ChrX, 4.66 cM, cytoband A1
• Alliance: Otc^spf page

Otc^spf/Otc^spf

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Radiation induced (Hypomorph)
• Mutation: Single point mutation
• Mutation details: A C to A missense transversion mutation in exon 4 changes a histidine to asparagine (H117N), creating a hypomorphic allele. About 10% of normal liver enzyme activity remains in mutant mice. (J:8786)
• Inheritance: Semidominant

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 9 strains available Cell Lines: 0 lines available
• Carrying any Otc Mutation: 22 strains or lines available

References

• Original: J:26975 Cupp MB, Sparse-fur, Sf. Mouse News Lett. 1958;19:37
• All: 33 reference(s)