T^c
Radiation induced Allele Detail

Summary

• Symbol: T^c
• Name: brachyury, T-box transcription factor T; curtailed
• MGI ID: MGI:1856185
• Gene: T Location: Chr17:8653255-8661328 bp, + strand Genetic Position: Chr17, 4.92 cM
• Alliance: T^c page

Mutation origin

• Strain of Origin: (C3H/HeH x 101/H)F1

Mutation description

• Allele Type: Radiation induced
• Mutation: Intragenic deletion
• Mutation details: Southern analysis of genomic DNA showed that this allele does not comprise a deletion of flanking loci, D17Leh119II and D17RP17, as found for alleles T^hp and T^Orl. Sequencing genomic DNA from the open reading frame revealed a 19 bp deletion of GCACACGGTCTCAGCTGCC predicted to result in a protein truncated at the carboxyl-terminal end. (J:85398)
• Inheritance: Semidominant

Expression

In Mice Carrying this Mutation:	74 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	20 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any T Mutation: 59 strains or lines available

Notes

T^c, curtailed, semidominant. Found among offspring from a cross between a multiple recessive testing stock, T stock, and a pup from an irradiated C3H/HeH female that had been impregnated by a 101/H male. Heterozygotes have complete or near-complete absence of the tail, absence of the odontoid process of the axis, absence of the nucleus pulposi of the intervertebral discs, a tendency for rib and vertebral fusions, and a slight decrease in average number of presacral vertebrae. They occasionally show paralysis of the hindlimbs and atresia ani. Homozygotes die at the same time as T/T embryos and are similar to them but more severely affected. T^c/T embryos are variable and intermediate between T/T and T ^c/T ^c (J:5003).

References

• Original: J:28887 Carter TC, et al., The genetic sensitivity to X-rays of mouse foetal gonads. Genet Res. 1960;1(3):351-5
• All: 15 reference(s)