Atp7b^tx
Spontaneous Allele Detail

Summary

• Symbol: Atp7b^tx
• Name: ATPase, copper transporting, beta polypeptide; toxic milk
• MGI ID: MGI:1856220
• Synonyms: tx
• Gene: Atp7b Location: Chr8:22482801-22550321 bp, - strand Genetic Position: Chr8, 10.78 cM
• Alliance: Atp7b^tx page

Mutation origin

• Strain of Origin: DL

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: An A-to-G transition point mutation at position 4066 of the coding sequence alters amino acid 1356 from methionine to valine in the encoded protein. This residue is predicted to lie within the eighth transmembrane domain and is highly conserved among copper transporting ATPases. (J:35781, J:114243)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atp7b Mutation: 82 strains or lines available

References

• Original: J:64103 Rauch H, tx - toxic milk. Mouse News Lett. 1977;56:48
• All: 19 reference(s)