Mcoln3^Va
Spontaneous Allele Detail

Summary

• Symbol: Mcoln3^Va
• Name: mucolipin 3; varitint waddler
• MGI ID: MGI:1856230
• Synonyms: TRPML3^Va, Va
• Gene: Mcoln3 Location: Chr3:145823205-145847561 bp, + strand Genetic Position: Chr3, 71.03 cM
• Alliance: Mcoln3^Va page

Krt25^Re/Krt25^Re Mcoln3^Va/Mcoln3^Va

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: (C57BL x C57BR)F1

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: The mutation in the Va mouse is a G-to-C transversion at coding nucleotide 1255 within exon 10. This results in a change from alanine to proline at amino acid 419 (p.A419P> which is in the fifth transmembrane domain. (J:80336)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mcoln3 Mutation: 35 strains or lines available

References

• Original: J:13133 Cloudman AM, et al., The varitint-waddler mouse. A dominant mutation in Mus musculus. J Hered. 1945;36(9):258-263
• All: 14 reference(s)