Kit^W-20J
Spontaneous Allele Detail

Summary

• Symbol: Kit^W-20J
• Name: KIT proto-oncogene receptor tyrosine kinase; dominant spotting 20 Jackson
• MGI ID: MGI:1856236
• Gene: Kit Location: Chr5:75735647-75817382 bp, + strand Genetic Position: Chr5, 39.55 cM
• Alliance: Kit^W-20J page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: Direct sequence of this allele and comparison with normal c-kit indicated a nonsynonymous coding mutation of a G-to-A point mutation in ATP biding loop consensus sequence of the kinase domain that result in replacement of the glycine with a glutamate residue at amino acid 595 position (p.G595E). (J:151778)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kit Mutation: 182 strains or lines available

References

• Original: J:6571 Geissler EN, et al., Analysis of pleiotropism at the dominant white-spotting (W) locus of the house mouse: a description of ten new W alleles. Genetics. 1981 Feb;97(2):337-61
• All: 2 reference(s)