Kit^W-f
Spontaneous Allele Detail

Summary

• Symbol: Kit^W-f
• Name: KIT proto-oncogene receptor tyrosine kinase; fertile dominant spotting
• MGI ID: MGI:1856261
• Gene: Kit Location: Chr5:75735647-75817382 bp, + strand Genetic Position: Chr5, 39.55 cM
• Alliance: Kit^W-f page

Mutation origin

• Strain of Origin: C3H/HePas

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: Analysis of cDNA showed this allele comprises an A-to-T transversion at coding nucleotide 2446 (transcript NM_021099) in the tyrosine kinase domain, producing a change from arginine to tryptophan at position 816 (p.R816W). (J:27513)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Kit Mutation: 182 strains or lines available

References

• Original: J:6187 Guenet JL, et al., Fertile dominant spotting in the house mouse. J Hered. 1979 Jan-Feb;70(1):9-12
• All: 6 reference(s)