Kit^W-v
Spontaneous Allele Detail

Summary

• Symbol: Kit^W-v
• Name: KIT proto-oncogene receptor tyrosine kinase; viable dominant spotting
• MGI ID: MGI:1856266
• Synonyms: Kit^Wv, W^', W², W^v, Wv
• Gene: Kit Location: Chr5:75735647-75817382 bp, + strand Genetic Position: Chr5, 39.55 cM
• Alliance: Kit^W-v page

Kit^W-v/Kit⁺ mouse

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: silvered black strain

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: A C-to-T point mutation at coding nucleotide 1979 (transcript NM_021099) results in a threonine to methionine substitution at amino acid 660 (p.T660M). (J:10528, J:24351)
• Inheritance: Semidominant

Disease models

Expression

In Mice Carrying this Mutation:	120 assay results 5 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	27 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Kit^W-v

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 10 strains available Cell Lines: 0 lines available
• Carrying any Kit Mutation: 182 strains or lines available

References

• Original: J:2447 Little CC, et al., The occurrence of a dominant spotting mutation in the house mouse. Proc Natl Acad Sci U S A. 1937 Oct;23(10):535-537
• All: 455 reference(s)