Eif3c^Xs-J
Spontaneous Allele Detail

Summary

• Symbol: Eif3c^Xs-J
• Name: eukaryotic translation initiation factor 3, subunit C; extra toes spotting Jackson
• MGI ID: MGI:1856274
• Gene: Eif3c Location: Chr7:126146083-126165538 bp, - strand Genetic Position: Chr7, 69.14 cM, cytoband F4
• Alliance: Eif3c^Xs-J page

Mutation origin

• Strain of Origin: C3H/HeJ

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: This allele was identified by a noncomplementation test result with Xs. A C-to-T point mutation (G-to-A on forward strand) in exon 9 results in a premature stop codon at arginine codon 303 (p.R303*). A a 50% reduction in total Eif3c mRNA levels is seen in homozygous animals. (J:172775)
• Inheritance: Semidominant

Expression

In Mice Carrying this Mutation:	61 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Eif3c Mutation: 31 strains or lines available

Notes

Salient features inferred from noncomplementaton test result report.

References

• Original: J:4291 Sweet HO, New allele of extra toes spotting. Mouse Genome. 1993;91(1):117
• All: 3 reference(s)