Yaa
Spontaneous Allele Detail

Summary

• Symbol: Yaa
• Name: accelerated autoimmunity and lymphoproliferation transposition; accelerated autoimmunity and lymphoproliferation
• MGI ID: MGI:1856277
• Synonyms: Is(XOfd1-Mid1;Y)1Mp, Tp(X;Y)1Ekw
• Gene: Yaa Location: unknown Genetic Position: ChrY, Syntenic

IL-21R deficiency prevents renal disease and mortality characteristic of BXSB-Yaa mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: SB/Le

Mutation description

• Allele Type: Spontaneous
• Mutations: Insertion, Translocation
• Mutation details: An approximately 4 MB region of the X chromosome that includes at least 13 known genes (spanning from Ofd1 to Mid1) was translocated to the Y chromosome adjacent to the pseudoautosomal region. Increased RNA expression of Msl3, Tlr7, Tmsb4x and Rab9 was detected in follicular B cells. (J:109758, J:111064, J:140028)

Disease models

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 24 strains available Cell Lines: 0 lines available
• Carrying any Yaa Mutation: 27 strains or lines available

References

• Original: J:6235 Murphy ED, et al., A Y chromosome associated factor in strain BXSB producing accelerated autoimmunity and lymphoproliferation. Arthritis Rheum. 1979 Nov;22(11):1188-94
• All: 101 reference(s)