Gli3^Pdn
Spontaneous Allele Detail

Summary

• Symbol: Gli3^Pdn
• Name: GLI-Kruppel family member GLI3; polydactyly Nagoya
• MGI ID: MGI:1856282
• Synonyms: Pdn
• Gene: Gli3 Location: Chr13:15638308-15904611 bp, + strand Genetic Position: Chr13, 5.43 cM, cytoband A2
• Alliance: Gli3^Pdn page

Mutation origin

• Strain of Origin: Jcl:ICR

Mutation description

• Allele Type: Spontaneous (Hypomorph)
• Mutation: Transposon insertion
• Mutation details: This hypomorphic allele was shown to contain a 5442 bp early retrotransponson in intron 3 by PCR analysis. The transposon was similar to a known retrotransposon, MMY17106, containing 317 bp long terminal repeats followed by 6 bp target duplication sequences at each end. RT-PCR analysis of homozygous mutant mice has shown several species of aberrant transcripts and indicated that the amount of message present in homozygous mutant mice is approximately 20% of the wild-type level. (J:18650, J:53808, J:82981)
• Inheritance: Semidominant

Expression

In Mice Carrying this Mutation:	109 assay results
In Structures Affected by this Mutation:	20 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gli3 Mutation: 81 strains or lines available

References

• Original: J:12736 Hayasaka I, et al., Polydactyly Nagoya, Pdn: A new mutant gene in the mouse. Jikken Dobutsu. 1980 Oct;29(4):391-5
• All: 32 reference(s)