Grem1^ld-J
Spontaneous Allele Detail

Summary

• Symbol: Grem1^ld-J
• Name: gremlin 1, DAN family BMP antagonist; limb deformity Jackson
• MGI ID: MGI:1856290
• Synonyms: Fmn^ld-J, footless, ld^J
• Gene: Grem1 Location: Chr2:113579020-113588993 bp, - strand Genetic Position: Chr2, 57.43 cM
• Alliance: Grem1^ld-J page

Mutation origin

• Strain of Origin: CBA/Ca-Bmp5^se

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: A G-to-A transition mutation at the boundary between intron 1 and exon 2 disrupts pre-mRNA splicing by eliminating the AG motif at the 3' splice acceptor site. The aberrant transcript expressed by this allele has a 65 base deletion of the 5' part of exon 2 and is missing the translational start codon. (J:43337, J:91385)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grem1 Mutation: 19 strains or lines available

References

• Original: J:171 Green MC, Limb deformity, ld. Mouse News Lett. 1962;26:34-5
• All: 13 reference(s)