Tyr^c-112K
Radiation induced Allele Detail

Summary

• Symbol: Tyr^c-112K
• Name: tyrosinase; albino 112, Oak Ridge
• MGI ID: MGI:1856308
• Synonyms: 112K, c^112K, c^E, c^E1'
• Gene: Tyr Location: Chr7:87073979-87142637 bp, - strand Genetic Position: Chr7, 49.01 cM
• Alliance: Tyr^c-112K page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Radiation induced
• Mutation: Intergenic deletion
• Mutation details: Large intergenic deletion. Tyr^c-65K and Tyr^c-112K are derived from the same male in matings sampling irradiated spermatogonial stem cells. They are presumed to have resulted from a single mutational event. (J:5386, J:23420)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tyr Mutation: 379 strains or lines available

Notes

The phenotype of mice carrying this allele is similar to Tyr^c-3H in most respects studied, including neonatal death, effect on liver enzymes and serum proteins (J:5435), and defective rough endoplasmic reticulum of liver (J:5386).

Compound heterozygotes carrying Tyr^c-ch show dilution of the chinchilla pigmentation compared to homozygous chinchilla mice (Tyr^c-ch/Tyr^c-ch, J:5435). Compound heterozygotes with Tyr^c-6H show reproductive activity however embryos died at about 8 days gestation (J;5435).

References

• Original: J:5435 Gluecksohn-Waelsch S, et al., Complementation studies of lethal alleles in the mouse causing deficiencies of glucose-6-phosphatase, tyrosine aminotransferase, and serine dehydratase. Proc Natl Acad Sci U S A. 1974 Mar;71(3):825-9
• All: 20 reference(s)