Clcn1^adr
Spontaneous Allele Detail

Summary

• Symbol: Clcn1^adr
• Name: chloride channel, voltage-sensitive 1; arrested development of righting response
• MGI ID: MGI:1856316
• Synonyms: adr, Clc, Clc-1/adr
• Gene: Clcn1 Location: Chr6:42263619-42292690 bp, + strand Genetic Position: Chr6, 20.57 cM
• Alliance: Clcn1^adr page

Mutation origin

• Strain of Origin: A2G

Mutation description

• Allele Type: Spontaneous
• Mutation: Transposon insertion
• Mutation details: Insertion of an ETn transposon disrupted sequences encoding D9, the ninth of twelve putative transmembrane domains. Northern analysis of skeletal muscle using a 5' rat Clcn1 cDNA probe detected aberrant size transcripts in homozygous mutant mice, but in the same tissues using a rat Clcn1 cDNA probe for sequences 3' to the D9 region, northern analysis detected no transcript. (J:752, J:24524)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Clcn1 Mutation: 71 strains or lines available

References

• Original: J:4480 Watkins WJ, et al., Biological features of the new A2G--adr mouse mutant with abnormal muscle function. Lab Anim. 1984 Jan;18(1):1-6
• All: 18 reference(s)