Atp7a^Mo-12H
Spontaneous Allele Detail

Summary

• Symbol: Atp7a^Mo-12H
• Name: ATPase, copper transporting, alpha polypeptide; mottled 12 Harwell
• MGI ID: MGI:1856324
• Gene: Atp7a Location: ChrX:105070882-105168532 bp, + strand Genetic Position: ChrX, 47.36 cM
• Alliance: Atp7a^Mo-12H page

Mutation origin

• Strain of Origin: (C3H/HeH x 101/H)F1

Mutation description

• Allele Type: Spontaneous
• Mutation: Undefined
• Mutation details: This mutation arose in mutagenesis studies at Harwell. Linkage and inheritance tests suggested that this is mutation is allelic to Mottled.
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atp7a Mutation: 69 strains or lines available

Notes

The mutation was found after induced in (C3H/HeH x 101/H)F1 males with hydroxyurea and X-rays, which were then mated to PT tester Stock females. Genetic analysis demonstrated that the mutation was derived from the PT tester stock, and is thought to be spontaneous.

References

• Original: J:16303 Rasberry C, et al., Three new mottled mutations - Mo^10H, Mo^11H, and Mo^12H. Mouse Genome. 1993;91(4):851-53
• All: 3 reference(s)