Dmd^mdx-2Cv
Chemically induced Allele Detail

Summary

• Symbol: Dmd^mdx-2Cv
• Name: dystrophin, muscular dystrophy; X linked muscular dystrophy 2, Verne Chapman
• MGI ID: MGI:1856329
• Synonyms: mdx^2cv
• Gene: Dmd Location: ChrX:81992476-84249747 bp, + strand Genetic Position: ChrX, 38.38 cM, cytoband C
• Alliance: Dmd^mdx-2Cv page

Mutation origin

• Strain of Origin: C3Ha.Cg-Hpr1t^a Pgk1^a

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: An A to T transversion two nucleotides 5' to the intron 42/exon 43 splice accesptor site. This mutation abolishes splicing at this site and induces aberrant splice products that do not preserve the reading frame. (J:34517)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dmd Mutation: 154 strains or lines available

References

• Original: J:9638 Chapman VM, et al., Recovery of induced mutations for X chromosome-linked muscular dystrophy in mice. Proc Natl Acad Sci U S A. 1989 Feb;86(4):1292-6
• All: 5 reference(s)