Cacng2^stg-wag
Spontaneous Allele Detail

Summary

• Symbol: Cacng2^stg-wag
• Name: calcium channel, voltage-dependent, gamma subunit 2; waggler
• MGI ID: MGI:1856386
• Synonyms: wag
• Gene: Cacng2 Location: Chr15:77875948-78004228 bp, - strand Genetic Position: Chr15, 36.92 cM
• Alliance: Cacng2^stg-wag page

Mutation origin

• Strain of Origin: MRL/MpJ-Fas^lpr/J

Mutation description

• Allele Type: Spontaneous
• Mutation: Other
• Mutation details: The phenotype of the waggler is associated with aberrant splicing residing in the first intron. Like the stargazer allele, a RT-PCR analysis demonstrated that in addition to aberrant transcripts, some normally spliced mRNA was detected, suggesting that this mutation does not represent a complete null allele. (J:48966)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cacng2 Mutation: 26 strains or lines available

Notes

Waggler is a second recessive mutation at the Cacng2 locus that arose in 1988 in the MRL/MpJ-Tnfrsf6 colony maintained at The Jackson Laboratory by Dr. Charles Sidman. Mutant homozygotes are characterized by whole body tremor, an unstable gait, and growth retardation. Hydrocephaly occurs occasionally. Hearing tests by Dr. Lawrence Erway of the University of Cinncinnati showed that the mutant was not deaf. Both sexes breed; no gross neuroanatomical or histopathologic lesions have been found (J:14313).

References

• Original: J:14311 Sweet HO, et al., Waggler (wag). Mouse Genome. 1991;89:552-53
• All: 7 reference(s)