Egfr^wa2
Spontaneous Allele Detail

Summary

• Symbol: Egfr^wa2
• Name: epidermal growth factor receptor; waved 2
• MGI ID: MGI:1856397
• Synonyms: wa-2, wa2, waved2
• Gene: Egfr Location: Chr11:16702203-16868158 bp, + strand Genetic Position: Chr11, 9.41 cM, cytoband A1-A4
• Alliance: Egfr^wa2 page

Mammary gland histology of an Egfr^wa2/Egfr^wa2 mouse

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: STOCK ac

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: A T-to-G transversion mutation in the sequences encoding the tyrosine kinase domain results in a substitution of a highly conserved valine with glycine at position 767 (P.V767G) in the third kinase subdomain. (J:16986)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	19 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Egfr^wa2

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Egfr Mutation: 87 strains or lines available

Notes

Found by Keeler in an ``abnormal corpus callosum'' stock at the Bussey Institution.

References

• Original: J:13052 Keeler CE, A second rexoid coat character in the house mouse. J Hered. 1935;26(5):189-191
• All: 71 reference(s)