Egfr^tm1Mag
Targeted Allele Detail

Summary

• Symbol: Egfr^tm1Mag
• Name: epidermal growth factor receptor; targeted mutation 1, Terry Magnuson
• MGI ID: MGI:1856402
• Synonyms: EGFR-, Egfr^m1Cwr, ErbB1^-
• Gene: Egfr Location: Chr11:16702203-16868158 bp, + strand Genetic Position: Chr11, 9.41 cM, cytoband A1-A4
• Alliance: Egfr^tm1Mag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:26833
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 155 bp containing part of exon 2. Aberrant splicing of the targeted exon was detected joining exon 1 to either exon 3 or exon 5. The former splicing event creates a nonsense protein. Although the latter splicing event produes a truncated mRNA, no protein or phosphorylation activity was detectable. (J:26833)

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	24 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Egfr Mutation: 87 strains or lines available

References

• Original: J:26833 Threadgill DW, et al., Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science. 1995 Jul 14;269(5221):230-4
• All: 29 reference(s)