Scn8a^med-TgA4Bs
Transgenic Allele Detail

Summary

• Symbol: Scn8a^med-TgA4Bs
• Name: sodium channel, voltage-gated, type VIII, alpha; motor end plate disease (TgA4Bs)
• MGI ID: MGI:1856414
• Synonyms: med^Tg, Med^TgScn8a, Scn8a^-, Scn8a^med-tg, Scn8a^medtg, Scn8a^med-tg1, Scn8a^med-TgNA4Bs
• Gene: Scn8a Location: Chr15:100767739-100943819 bp, + strand Genetic Position: Chr15, 56.39 cM, cytoband F1
• Alliance: Scn8a^med-TgA4Bs page

Transgene origin

• Strain of Origin: (C57BL/6J x C3H)F2

Transgene description

• Transgene Type: Transgenic
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 20kb deletion was detected at the transgene insertion site, with no evidence of additional rearrangement of the chromosomal DNA. This insertion and deletion cause expression of Scn8a to be disrupted. Expression from the inserted transgene was detected in the liver. (J:27739)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn8a Mutation: 99 strains or lines available

References

• Original: J:24228 Kohrman DC, et al., Insertional mutation of the motor endplate disease (med) locus on mouse chromosome 15. Genomics. 1995 Mar 20;26(2):171-7
• All: 17 reference(s)