Reln^rl-Orl
Spontaneous Allele Detail

Summary

• Symbol: Reln^rl-Orl
• Name: reelin; reeler Orleans
• MGI ID: MGI:1856416
• Synonyms: Reln^Orl
• Gene: Reln Location: Chr5:22089452-22549700 bp, - strand Genetic Position: Chr5, 9.98 cM, cytoband A3-B1
• Alliance: Reln^rl-Orl page

Mutation origin

• Strain of Origin: BALB/c

Mutation description

• Allele Type: Spontaneous
• Mutation: Transposon insertion
• Mutation details: Sequence analysis of genomic DNA from mutant mice showed showed a 7.1 kb LINE 1 sequence bordered at both ends by a direct repeat from the integration site within an exon that encodes the eigth EGF-like motif of the Reln protein. Nucleotide sequence analysis of showed that the LINE insertion caused this exon to be skipped during transcription leading to a 220 bp deletion in the Reln mRNA. (J:34099)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	31 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Reln Mutation: 209 strains or lines available

References

• Original: J:29622 Guenet JL, Mutant Stocks: Alphabetical list of named mutant genes (except T locus alleles). Mouse News Lett. 1978;59:50-54
• All: 25 reference(s)