Pmp22^Tr-Ncnp
Spontaneous Allele Detail

Summary

• Symbol: Pmp22^Tr-Ncnp
• Name: peripheral myelin protein 22; trembler National Center of Neurology and Psychiatry
• MGI ID: MGI:1856420
• Synonyms: Tr-Ncnp
• Gene: Pmp22 Location: Chr11:63019808-63050373 bp, + strand Genetic Position: Chr11, 38.99 cM
• Alliance: Pmp22^Tr-Ncnp page

Mutation origin

• Strain of Origin: GAD/Ncnp

Mutation description

• Allele Type: Spontaneous
• Mutation: Intragenic deletion
• This allele comprises an inframe deletion of about 17 kb that includes exon IV. (J:43874, J:51487)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pmp22 Mutation: 33 strains or lines available

References

• Original: J:43874 Suh JG, et al., An in-frame deletion in peripheral myelin protein-22 gene causes hypomyelination and cell death of the Schwann cells in the new Trembler mutant mice. Neuroscience. 1997 Aug;79(3):735-44
• All: 5 reference(s)