Pcdh15^av
Spontaneous Allele Detail

Summary

• Symbol: Pcdh15^av
• Name: protocadherin 15; Ames waltzer
• MGI ID: MGI:1856467
• Synonyms: av
• Gene: Pcdh15 Location: Chr10:72935174-74485569 bp, + strand Genetic Position: Chr10, 37.43 cM
• Alliance: Pcdh15^av page

Mutation origin

• Strain of Origin: K

Mutation description

• Allele Type: Spontaneous
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pcdh15 Mutation: 135 strains or lines available

Notes

Pcdh15^av is a waltzing type mutation that arose in the K strain and is inherited independently of the Cdh23^v waltzer mutation (J:14990). Viability and fertility are about normal, but females are poor mothers. Homozygotes show the typical circling, head-tossing, deafness, and hyperactivity of the circling mutants. Later, hair cells and spiral ganglion cells degenerate. The permeability of the stria vascularis appears to be normal (J:5225). This mutation is probably extinct (J:106625).

References

• Original: J:14990 Schaible RH, av. Mouse News Lett. 1957;15:29
• All: 9 reference(s)