Foxn1^nu-Y
Spontaneous Allele Detail

Summary

• Symbol: Foxn1^nu-Y
• Name: forkhead box N1; nude Yurlovo
• MGI ID: MGI:1856502
• Gene: Foxn1 Location: Chr11:78248403-78277384 bp, - strand Genetic Position: Chr11, 46.74 cM
• Alliance: Foxn1^nu-Y page

Mutation origin

• Strain of Origin: 101/HY

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: A point mutation resulting in the C-to-T transition at nucleotide 1051 (accession# X81593) located in exon 7, leads to the replacement of an arginine with a cysteine at amino acid 320 (p.R320C). Although mutant protein is detectable in the nucleus, there was no detectable activation of the Krt2-18 target gene. (J:61394)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxn1 Mutation: 106 strains or lines available

References

• Original: J:4060 Ignat'eva EL, et al., Athymic Mice of Inbred Strain 101/Hy with a New Allele at the Nude Locus. Biull Eksp Biol Med. 1992;113(1):111-4
• All: 3 reference(s)