Cacng2^stg
Spontaneous Allele Detail

Summary

• Symbol: Cacng2^stg
• Name: calcium channel, voltage-dependent, gamma subunit 2; stargazer
• MGI ID: MGI:1856548
• Synonyms: gamma2^stg, stg, stg^-
• Gene: Cacng2 Location: Chr15:77875948-78004228 bp, - strand Genetic Position: Chr15, 36.92 cM
• Alliance: Cacng2^stg page

The Cacng2^stg/Cacng2^stg mouse

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: A/J

Mutation description

• Allele Type: Spontaneous
• Mutation: Transposon insertion
• Mutation details: The phenotype of the stargazer mouse has been attributed to an early transposon (ETn) insertion into intron 2 of the Cacng2 gene. RT-PCR analysis demonstrated that in addition to aberrant transcripts generated by the insertion, some normally spliced mRNA was detected, suggesting that this mutation does not represent a complete null allele. (J:48966)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cacng2 Mutation: 26 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Absence Epilepsy J:192431, J:155872, J: 226251.

References

• Original: J:11008 Noebels JL, et al., Stargazer: a new neurological mutant on chromosome 15 in the mouse with prolonged cortical seizures [published erratum appears in Epilepsy Res 1992 Mar;11(1):72]. Epilepsy Res. 1990 Nov;7(2):129-35
• All: 68 reference(s)