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tw5
Spontaneous Allele Detail
Summary
Symbol: tw5
Name: t-complex; t, wild 5
MGI ID: MGI:1856570
Synonyms: tcl-w5, t-complex lethal w5
Gene: t  Location: unknown  Genetic Position: Chr17, Syntenic
Alliance: tw5 page
Mutation
origin
Strain of Origin:  wild-derived
Mutation
description
Allele Type:    Spontaneous
Mutations:    Inversion, Nucleotide repeat expansion
 
Mutation detailsThis t haplotype includes a mutation in Vps52, Vps52t-w5 that inserts 2 G nucleotides at the start of exon 2 in a stretch of consecutive G nucleotides (9 in the wild-type C57BL/6 sequence) resulting in a frameshift mutation that generates a premature termination codon. The mutation in Vsp52 is responsible for the embryonic lethal homozygous phenotype in this haplotype. (J:190873)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any t Mutation:  19 strains or lines available
Notes
This homozygous lethal allele originated in a mouse caught in the New York suburbs. It suppresses recombination and is a member of the complementation group: tw5 ,tw6 ,tw10 ,tw11 ,tw13 ,tw14 ,tw15 ,tw16 ,tw17 ,tw37 , tw38 ,tw39 ,tw41 ,tw46 ,tw47 ,tw74 ,tw75 ,tw80 ,tw81. T/tw5 phenotype is tail-less.
    Embryos homozygous for tw5 arrest at gastrulation and exhibit defects in proliferation/differentiation of embryonic ectoderm.
References
Original:  J:23652 Dunn LC, et al., Studies of the Genetic Variability in Wild Populations of House Mice. I. Analysis of Seven Alleles at Locus T. Genetics. 1956 May;41(3):344-52
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory