Tgfa^tm1Ard
Targeted Allele Detail

Summary

• Symbol: Tgfa^tm1Ard
• Name: transforming growth factor alpha; targeted mutation 1, Ashley R Dunn
• MGI ID: MGI:1856577
• Synonyms: Tgfalpha -
• Gene: Tgfa Location: Chr6:86172205-86252701 bp, + strand Genetic Position: Chr6, 37.62 cM
• Alliance: Tgfa^tm1Ard page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:4606
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin cassette was inserted into exon 3 of the gene. (J:4606)

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tgfa Mutation: 17 strains or lines available

Notes

In conjunction with Fgf7^tm1Efu, double homozygous mutant mice display no additional abnormalities nor increase in severity of phenotypes over individual homozygous mutants. (J:31155)

References

• Original: J:4606 Mann GB, et al., Mice with a null mutation of the TGF alpha gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation. Cell. 1993 Apr 23;73(2):249-61
• All: 17 reference(s)