Tyr^c-14CoS
Radiation induced Allele Detail

Summary

• Symbol: Tyr^c-14CoS
• Name: tyrosinase; albino deletion 14CoS, Oak Ridge
• MGI ID: MGI:1856580
• Synonyms: c^14CoS, c^A1, Fah-
• Gene: Tyr Location: Chr7:87073979-87142637 bp, - strand Genetic Position: Chr7, 49.01 cM
• Alliance: Tyr^c-14CoS page

Mutation origin

• Strain of Origin: (101 x C3H)F1

Mutation description

• Allele Type: Radiation induced
• Mutation: Intergenic deletion
• Large intergenic deletion. (J:5435)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tyr Mutation: 379 strains or lines available

Notes

Tyr^c-14CoS. This induced mutation was found at Oak Ridge National Laboratory. Homozygotes die neonatally (J:5063), and have deficiencies in activity of at least five liver enzymes, glucose-6-phosphatase, tyrosine aminotransferase, serine dehydratase, glutamine synthetase, and UDP-glucuronyltransferase, as well as low levels of liver microsomal cytochrome P-450 and the plasma proteins, albumin, a-fetoprotein, and transferrin (J:5715, J:5588, J:5730). Control of the level of two enzymes occurs at the transcriptional level; control of the level of the three plasma proteins occurs posttranscriptionally (J:7838, J:7840). There is a marked decrease in the number of receptors for insulin and glucocorticoids (J:6996) and for epidermal growth factor and glucagon (J:12047). Two specific liver polypeptides recognizable in two-dimensional gels are lacking (J:7420). The rough endoplasmic reticulum of the liver, and to a lesser extent of the kidneys, is dilated and vesiculated (J:5386). Complementation studies with other alleles have shown that this is probably the shortest of the six deletions (J:5435). It is known not to include the Mod2 locus (J:5437).

Compound heterozygotes carrying Tyr^c-ch show dilution of the chinchilla pigmentation compared to homozygous chinchilla mice (Tyr^c-ch/Tyr^c-ch, J:5435).

References

• Original: J:5063 Erickson RP, et al., Glucose-6-phosphatase deficiency caused by radiation-induced alleles at the albino locus in the mouse. Proc Natl Acad Sci U S A. 1968 Feb;59(2):437-44
• All: 30 reference(s)