Lgi4^clp
Spontaneous Allele Detail

Summary

• Symbol: Lgi4^clp
• Name: leucine-rich repeat LGI family, member 4; claw paw
• MGI ID: MGI:1856594
• Gene: Lgi4 Location: Chr7:30758767-30770360 bp, + strand Genetic Position: Chr7, 19.29 cM
• Alliance: Lgi4^clp page

Mutation origin

• Strain of Origin: B6.Cg-Lep^ob/J

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Insertion
• Mutation details: A CTCT repeat located six base pairs 5' to exon 4 is replaced with a 225-bp repetitive sequence which is 100% homologous to a repeat element located 797 bp upstream. This interferes with the third intron 3' splice site resulting in exon3 spliced to exon 5. The resulting protein, lacking exon 4, is not secreted as is the wild-type allele. (J:105260)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Lgi4^clp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lgi4 Mutation: 33 strains or lines available

Notes

This mutation arose at The Jackson Laboratory in 1977. The pathology of homozygous mutant mice differs from other myelin deficient mutants in that there is no obvious increase in Schwann cells and that the axons that persist in promyelin fibers are smaller (J:11392).

References

• Original: J:24743 Henry E, et al., Claw paw, a new mutation affecting peripheral nerves. Mouse News Lett. 1987;78:46
• All: 9 reference(s)